Rank the following one-base point mutations with respect to their likelihood of affecting the structure of the corresponding polypeptide (from most likely to least likely).
1. insertion mutation deep within an intron 2. substitution mutation at the third position of a codon in an exon 3. substitution mutation at the second position of a codon in an exon
4. deletion mutation within the first exon of the gene (A) 1,2,3,4 (B) 4,3,2,1 (C) 2,1,4,3 (D) 3,1,4,2