Which of the following conditions will activate pyruvate dehydrogenase kinase, which catalyzes
the phosphorylation and inactivation of E1 in the pyruvate dehydrogenase complex?
A) Ca2+
B) Insulin
C) Elevated concentrations of acetyl-CoA
D) Elevated concentrations of NAD+ and ADP
E) Elevated concentrations of NADH and ATP