In humans , the antibiotic Ceftriaxone has the mean values for the apparent volume of
distribution 300 L and total clearance CL=14L/h and t1/2= 8 h. . Salmonella infection is
susuceptible to Ceftriaxone at concntration above 5 ug/mL and patient gets overdosed at
the levels above 80ug/L.
Calculate an IV dose ad infusion rate that provides steady-state level of 30ug/mL in human.
b)The doctor decides to give a dose of 12 mg and started a constatnt infusion at the same
Ro calculated . Ceftriaxone is eliminated as unchanges in the urine and the drug
concentrations were recorded as ;
Time (h.) 0 12 24 36 360
Con. Ug/L 4 6 6.8 7.5 10
a) Compute the Vd for patient .
b) Compute the CL .