Sally, a 52-year-old woman, is experiencing swelling and inflammation in her right hand accompanied by a mild rash and progressive loss of function due to increased stiffness. Lab testing shows an increase in ESR, CRP, and the presence of RF (rheumatoid factor). Which of the following is not a possible cause or risk factor of this condition?
1) Heredity
2) Alcohol abuse
3) Smoking
4) Old age
5) Genetic makeup includes XX