Which of the following statements are accurate regarding Nucleoside Reverse Transcriptase Inhibitors (NRTIs)? (Select ALL that apply.)
A. The entire class has a boxed warning for pancreatitis.
B. The entire class has a boxed warning for Stevens-Johnson Syndrome.
C. They interfere with the action of reverse transcriptase, blocking viral DNA synthesis.
D. The entire class has a boxed warning for lactic acidosis.
E. They do not undergo hepatic transformation via the CYP 450 pathway.