Which of the following is most responsible for the specificity of interaction between the aminoacyl-trna and the complementary mrna codon?
1) Hydrogen bonding between the bases of the codon and anticodon
2) Covalent bonding between the amino acid and the trna
3) Hydrophobic interactions between the trna and the ribosome
4) Electrostatic interactions between the trna and the ribosome