How can the leading and lagging strands be synthesized in a coordinated fashion?
a. The lagging strand is extended in the 3´-to-5´ direction and the leading strand is extended in the 5´-to-3´ direction.
b. Specific enzymes control the size of the DNA opening.
c. Pol III is a dimeric holoenzyme, and the looped lagging strand allows the enzyme to proceed in the same direction with each strand.
d. Lagging-strand binding proteins inhibit leading-strand replication if the strands become disproportionate in size.