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If cohesin was not produced, or not functional, what would be the effect on mitosis? if cohesin was not produced, or not functional, what would be the effect on mitosis? sister chromatids cannot be attached to spindle fibers. sister chromatids cannot be separated during mitosis. sister chromatids may drift apart after being synthesized. sister chromatids would not be synthesized.

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Answer;

Sister chromatids may drift apart after being synthesized.

Explanation;

-Cohesin is a protein which localizes between the sister chromatids and holds them together to resist the pull of the kinetochore microtubules.

-Because cohesin enables sister chromatids to remain attached from the time they are synthesized during S phase until the end of metaphase. If cohesin is defective, sister chromatids may separate before they normally would in anaphase, which would lead to daughter cells that have too few or too many chromosomes.

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