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Which of the following statements is true? Proteins destined for the ER are translated by a special pool of ribosomes whose subunits are always associated with the outer ER membrane. Proteins destined for the ER are translated by cytosolic ribosomes and are targeted to the ER when a signal sequence emerges during translation. Proteins destined for the ER translocate their associated mRNAs into the ER lumen where they are translated. Proteins destined for the ER are translated by a pool of cytosolic ribosomes that contain ER-targeting sequences that interact with ER-associated protein translocators

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Answer: the correct answer is Proteins destined for the ER are translated by cytosolic ribosomes and are targeted to the ER when a signal sequence emerges during translation.

Explanation:

ER means Endoplasmic Reticulum and it works as a manufacturing and packaging system.

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The statement 'proteins destined for the ER are translated by cytosolic ribosomes and are targeted to the ER when a signal sequence emerges during translation' is TRUE.

The endoplasmic reticulum, Golgi apparatus and lysosomes are part of the endomembrane system.

Proteins destined for incorporation into the endoplasmic reticulum are initially targeted to this organelle.

The ER signal sequence is a hydrophobic aminoacidic region of the protein located at the N-terminal end which is recognized by the signal-recognition particle (SRP) and its receptor located on the rough endoplasmic reticulum membrane.

In conclusion, the statement 'proteins destined for the ER are translated by cytosolic ribosomes and are targeted to the ER when a signal sequence emerges during translation' is TRUE.

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