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The cell's proteins are first manufactured in the ribosomes. The polypeptide chains then enter the lumen of the Rough Endoplasmic Reticulum where they are properly folded with the help of chaperones and modified to achieve their desired shape which relates to their function. The proteins also undergo quality control in the RER, These proteins are then transported by vesicles, budding out of the trans side of the RER, and transported to the cis side of the Golgi apparatus. In the Golgi bodies, the proteins undergo further post-translational modification and packaging. Vesicles carrying the final proteins then bud off of the trans side of the Golgi apparatus and transport the protein to the cell membrane where they secreted them.

The protein is made in the ribosome organelle, secreted by transport vesicles using a type of transport called exocytosis.
- Proteins are products of gene expression, which consists of transcription and translation of genetic material to produce them.
- The translation process, which occurs in the ribosomes, produce amino acids sequence that eventually become proteins.
- Ribosomes are site of protein synthesis in a cell. The proteins are secreted to target locations via the aid of structures called transport vesicles.
- Transport vesicles, carrying proteins, attach themselves to the cell membrane and release their protein content via the process of exocytosis.
- Therefore, protein is made in the ribosome organelle, secreted by transport vesicles using a type of transport called exocytosis.
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