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Total nucleic acids are extracted from a culture of cells and are then mixed with resin beads to which the polynucleotide 5'-TTTTTTTTTTTTTTTTTTTTTT-3' has been covalently attached. After a short incubation, the beads are then extracted from the mixture. When you analyze the cellular nucleic acids that have stuck to the beads, which of the following molecules do you expect to be most abundant?

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Answer:

Molecules which have adenine rich sequences

Explanation:

  • The resin beads are attached to a polynucleotide made solely of thymine.
  • The complementary nucleotide base to thymine would be adenine and thus sequences with lots of adenine will bind t the beads with a higher affinity than beads with few adenine bases.

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