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The enzyme phosphofructokinase is an allosteric enzyme that is regulated by products produced from glycolysis, the citric acid cycle, and oxidative phosphorylation. Considering the overall result of glycolysis, would you expect an excess of ATP to stimulate or inhibit the activity of this enzyme? What type of feedback cycle would this be considered? Explain.

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Explanation:

The overall result of glycolysis, the citric acid cycle and oxidative phosphorylation is to oxidize glucose to produce CO₂, water and ATP.

If there is an excess of ATP in the cell, there is no need to keep breaking down glucose to generate more, so the phosphofructokinase enzyme would be inhibited. This is an example of negative feedback: the accumulation of the product of a reaction stops or slows down the process that produces it.

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