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Which of the following statements about aminoacyl-tRNA synthetases is false?

A) Some of the enzymes have an editing/proofreading capability.
B) The enzyme attaches an amino acid to the 3' end of a tRNA.
C) The enzyme splits ATP to AMP + PPi.
D) The enzyme will use any tRNA species but is highly specific for a given amino acid.
E) There is a different synthetase for every amino acid.

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Answer:

The correct answer is option D) "The enzyme will use any tRNA species but is highly specific for a given amino acid".

Explanation:

Aminoacyl-tRNA synthetases, also known az tRNA-ligase, are the enzymes that catalyze the attachment of the appropriate amino acid onto its tRNA. It is false to affirm that these enzymes will use any tRNA species but is highly specific for a given amino acid. In fact, aminoacyl-tRNA synthetases are highly specific for both, tRNA species and amino acids. Kinetic studies show that aminoacyl-tRNA synthetases reject wrong tRNAs during catalysis.

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