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The benefit of measuring the initial rate of a reaction V₀ is that at the beginning of a reaction: A) [ES] can be measured accurately. B) changes in [S] are negligible, so [S] can be treated as a constant. C) changes in Km are negligible, so Km can be treated as a constant D) V₀ = [tex]V_{max}[/tex]. E) varying [S] has no effect on V₀

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Answer:

C) changes in Km are negligible, so Km can be treated as a constant

Explanation:

Hello,

Biochemical reactions have been widely modeled by Michaelis through His well-known equation:

[tex]Vo=\frac{V_{max}[S]}{Km+[S]}[/tex]

Thus, in order to correctly assure the value of the initial rate of the reaction allows the calculation of Km, therefore changes in Km are negligible, so Km can be treated as a constant as long as it is the substrate concentration at half of the maximum rate, in fact, Km is known as the Michaelis constant.

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