How many molecules of ATP are generated when stearic acid , an 18-carbon saturated fatty acid, is completely oxidized via the beta-oxidation pathway in the mitochondria?

a) 112
b) 129
c) 146
d) 163

Respuesta :

Answer:

(c) . 146

Explanation:

To calculate the ATP generated in complete beta-oxidation of stearic acid (an 18-carbon saturated fatty acid ),

     number of rounds of beta-oxidation = [tex]n/2 - 1[/tex]   ,

                                           where ,n is number of carbon present in fatty acid                                        since , n= 18 in give fatty acid

      number of rounds of beta-oxidation = [tex]18/2 - 1 = 8[/tex]

 8 rounds of beta-oxidation gives :-

    -8[tex]NADH[/tex]

    -8[tex]FADH_{2}[/tex]

    -8 [tex]Acetyl-CoA[/tex] + [tex]Acetyl-CoA[/tex]

   Each rounds of beta oxidation gives 17 ATP , So 8 rounds of beta-     oxidation gives 17 × 8 = 136 ATP , while theres's an extra [tex]Acetyl-CoA[/tex] which also undergoes in Krebs cycle along with other 8 [tex]Acetyl-CoA[/tex] , though this extra [tex]Acetyl-CoA[/tex] produce 12 ATP . While 2 molecules of ATP is consumed in activation of fatty acid , So total energy generated in beta-oxidation of stearic acid is 146 .