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This is the concept of immunoendocrinology.A pratical example is the interaction between pineal gland(endocrine gland) and immune system. Pineal gland  secrets melatonin.(hormone that regulate sleep-wake cycle) ,

Evidence has shown that interleukin 1 beta  inhibits secretion of melatonin by the pineal gland through  suppression of arylalkylamine-N-acetyltransferase (AA-NAT) protein expression which lead to  inhibition of melatonin secretion.

The activities of small non coding RNA molecules-Micro-RNAs in exerting effects on the biological process at different levels is another example. These RNAs have effects on the autoimmune diabetes.

 Specifically Micro-RNAs exerts  functional regulatory  effects at  cells,tissues, organs levels between the pancreatic beta cells and the immune systems. Thus the interaction provided by these RNA plays a major role in understanding the effects of relationship between the immune systems and beta cells of the pancreas for autoimmune diabetes

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