___ que uds. son muy inteligentes y simpáticos.

Creo que uds. son muy inteligentes y simpáticos.
The translation of the given spanish sentence to english is;
___ that you are very intelligent and friendly.
Now, this is a statement that requires an action word to complete it and the action word we can use here will be "I know".
The translation of "I know" to spanish is "Creo".
Thus, the correct option is option C which is Creo.
Read more about Spanish Sentences at; https://brainly.com/question/7150507
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