Answer:
Total ATP molecules produced = 66 molecules of ATP
Explanation:
A 10-carbon fatty acid when it has undergone complete oxidation will yield 5 acetyl-CoA molecules and 4 FADH₂ and 4 NADH molecules each. Each of the 5 acetyl-CoA molecules enters into the citric acid cycle and is completely oxidized to yield further ATP and FADH₂ and NADH molecules.
The total yield of ATP in the various enzymatic step is calculated below:
Acyl-CoA dehydrodenase = 4 FADH₂
β-Hydroxyacyl-CoA dehydrogenase = 4 NADH
Isocitrate dehydrogenase = 5 NADH
α-Ketoglutarate dehydrogenase = 5 NADH
Succinyl-CoA synthase = 5 ATP (from substrate-level phosphorylation of GDP)
Succinate dehydrogenase = 5 FADH₂
Malate dehydrogenase = 5 NADH
Total ATP from FADH₂ molecoles = 9 * 1.5 = 13.5
Total NADH molecules = 19 * 2.5 = 47.5
Total ATP molecules produced = 13.5 + 47.5 + 5
Total ATP molecules produced = 66 molecules of ATP
Answer:
Explanation:
First, calculate the number of acetyl-CoA molecules formed:
Number of acetyl-CoA molecules = [tex]\frac{number of carbons in fatty acid}{2}[/tex]
[tex]= \frac{10}{2}\\\\ = 5 acetyl-CoA molecules[/tex]
Next, calculate the number of rounds of beta-oxidation:
Number of rounds = number of acetyl-CoA molecules - 1
[tex]= 5 - 1\\\\ = 4 rounds[/tex]
Calculate the number of ATP from NADH and FADH2:
If each NADH yields 2.5 ATPs and each FADH2 yields 1.5 ATPs, then multiply the number of rounds by 4 and multiply the number of acetyl-CoA molecules by 10.
[tex](4 * 4) + (5 * 10) = 66 ATP[/tex]
Subract two ATP molecules for activation of the fatty acid.
[tex]Total ATP = 66 - 2\\\\ = 64 ATPs[/tex]
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