Individuals can take a course of antibiotics to help their immune system fight bacterial diseases. Which of the following best explains why these antibiotics may lose their effectiveness against certain bacteria?

Antibiotics have become diluted and weak because of a limited supply.

Resistant bacteria are polyploidy and can resist the antibiotic, a trait that is passed on to their offspring.

Some bacteria have randomly mutated to resist the antibiotic, and this resistance is inherited.

Bacteria have purposefully directed their immune system to resist the effect of the antibiotic.

Antibiotic resistance is a serious health issue that occurs when bacteria gains resistance against certain antibiotics, which reduces or eliminates the effectiveness of the treatments. The best explanation for this phenomenon is that some bacteria have randomly mutated to resist the antibiotic, and this resistance is inherited. This happens particularly when people do not take the full treatment or take treatment without diagnosis. In consequence, the populations of bacteria are not fully eliminated, increasing the probability of survival for bacteria that randomly mutates towards resisting the treatment.