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The French and Indian War began over the specific issue of whether the upper Ohio River valley was a part of the British Empire, and therefore open for trade and settlement by Virginians and Pennsylvanians, or part of the French Empire.

French and Indian War/Seven Years' War, 1754–63. ... The war provided Great Britain enormous territorial gains in North America, but disputes over subsequent frontier policy and paying the war's expenses led to colonial discontent, and ultimately to the American Revolution.