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Although Wilmot opposed the extension of slavery into the territories, he was generally considered to be a Democratic Party loyalist; he supported Polk in the initiation of the Mexican-American War and was the lone House Democrat from Pennsylvania to vote for the Walker tariff.
He is best known for being the prime sponsor and namesake of the eponymous Wilmot Proviso, a failed proposal to ban the expansion of slavery to western lands gained in the Mexican Cession.