Answer: Spread of diseases like chickenpox and smallpox.
Explanation:
The spread of infectious diseases among the natives was the greatest negative consequence between the natives of North America and the Europeans. The natives did not have developed immunity to certain infectious diseases. These epidemics sometimes decimated entire tribal communities. According to available historical sources, most of the natives died of infectious diseases. In some communities, there was no one to cultivate the land and go hunting, because most natives were infected, so sometimes they died of starvation.