When a mutation renders a gene or protein unable to function properly, this is called a gene variant.
A mutation is defined as sudden, stable, and inheritable changes in the genetic sequences of organisms.
Mutations in the genetic sequences furnish a gene or protein to function abnormally, due to this several genetic disorders arise in the offspring. It prevents one or more proteins from working properly.
Therefore, when a mutation renders a gene or protein unable to function properly, this is called a gene variant.
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