In normal cells, stathmin is inactivated by phosphorylation at the start of M phase. Phosphatases remove these phosphates as the cell transitions from M phase to G1. What enzyme is likely to be responsible for phosphorylating stathmin during M phase

This enzyme is also known as cyclin dependent kinase subunit, CDKs. they are protein kinases and can function as cell cycle regulators. They have the power to modify different protein substrates that are useful for the progression of cell cycle. CDKs are inhibitors hence stathmin is inactivated by phosphorylation. They help to control cell divisions. DNA should not be damaged for cell to move from G₁ to the S phase.

throwdolbeau throwdolbeau · Answer 2 · 2021-12-15T05:56:57+01:00

The enzyme that is likely to be responsible for phosphorylating stathmin during M phase is the cyclin dependent kinase.

Cyclin-dependent kinases:

Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate subunit - a cyclin - that provides domains essential for enzymatic activity.
CDKs play important roles in the control of cell division and modulate transcription in response to several extra- and intracellular cues.
CDKs are inhibitors hence stathmin is inactivated by phosphorylation. They help to control cell divisions. DNA should not be damaged for cell to move from G₁ to the S phase.
Full kinase activity requires an activating phosphorylation on a threonine adjacent to the CDK's active site.

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