A small proportion of humans have resistance to strains of HIV, the virus that causes AIDS. Their immunity is caused by a deletion in gene CCR5, a co-receptor on white blood cells needed for HIV infection. The proportion of people with resistance (genotype aa) to HIV is approximately 8%. If these alleles are in Hardy Weinberg equilibrium, what proportion of people are carriers for the HIV resistant allele?

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Answer:

The correct answer is "40.6%". A further explanation is provided below.

Explanation:

The given values are:

The proportion of people with resistance is,

aa = 8%

or,

    = 0.08 (q²)

= 0.08

q   = √0.08

    = 0.28284

Now,

⇒ [tex]p+q=1[/tex]

⇒       [tex]p=1-q[/tex]

             [tex]=1-0.28284[/tex]

             [tex]=0.717157[/tex]

hence,

For the HIV resistant allele, the proportion of people will be:

= [tex]Aa[/tex]

= [tex]2pq[/tex]

On substituting the values, we get

= [tex]2\times 0.71715\times 0.28284[/tex]

= [tex]0.4056[/tex]

= [tex]40.6[/tex] (%)

The proportion of the population with the carrier of HIV-resistant allele is 40.56%.

What is Hardy Weinberg equilibrium?

Hardy Weinberg equilibrium is the relationship between the variation from one generation to the next. The equation for the relationship can be given as:

[tex]p^2+2pq+q^2=1[/tex]

Where the proportion of dominant alleles is p².

The proportion of recessive alleles is .

The proportion with the caries are 2pq.

The given recessive allele proportion in the population is 0.08. The proportion of dominant alleles can be given as:

[tex]q^2=0.08\\q=0.2828[/tex]

The dominant alleles can be given as:

[tex]p+q=1\\p+0.28284=1\\p=0.717157[/tex]

The carriers in the population can be given as:

[tex]\text{Carriers}=2pq\\\text{Carriers}=2\;\times\;0.717157\;\times\;0.2828\\\text{Carriers}=0.4056\\\text{Carriers}=40.56\%[/tex]

Thus, the carriers for the HIV gene in the population are 40.56%.

Learn more about Hardy Weinberg equilibrium, here:

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