Answer:
What prevents these microorganisms from spreading resistance outside the laboratory is that they are modified to not survive outside the laboratory environment.
Explanation:
Antibiotic resistant microorganisms are very dangerous and unfavorable, as they leave living beings completely completely defenseless to their attacks. However, there are microorganisms that have been modified in the laboratory, as shown in the question above, and do not present any risk to living beings, even if they develop resistance. This is because the modification that these microorganisms received makes them not survive the environmental conditions outside the laboratory, which causes them to die if they leave the laboratory.