The incidence of spinal muscular atrophy (an autosomal recessive disease) in the United States is about 1 case in every 17,000. Whereas, in North Dakota, the prevalence is 1 in 6720. Which of the following would support the hypothesis that genetic drift was responsible for the increased allele frequency in North Dakota?
A. There is an abnormally high concentration of mutagenic chemicals in the ground water causing an increased mutation rate in North Dakota.
B. One of the best treatment centers for SMA is located in North Dakota causing migration of SMA carriers into the area at an abnormally high frequency
C. The original settlers of North Dakota were a small group of pioneers who happened to have an abnormally high frequency of the SMA allele in their population.
D. A particular mosquito-born parasite native to North Dakota causes high infant mortality; carriers of the SMA allele are less likely to catch the disease.

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ashwinvt ashwinvt · Answer 2 · 2022-08-17T10:53:55+02:00

Genetic drift says it is a random selection of a genetic variant that causing a change in allele frequency in a population.

One of the best treatment centers for Spinal Muscular Atrophy is located in North Dakota causing migration of SMA carriers into the area at an abnormally high frequency. Thus option B is correct.

What is spinal muscular atrophy?

It is a group of autosomal recessive inherited disorders cause progressive muscle degeneration and weakness. One of the second leading neuromuscular disease.

Three types of SMA affect only children of less than 1 year and , type IV and Finkel type observed in adult, Symptoms in adult include weakness in muscles, tremor etc.

Type 1 SMA seen during birth symptoms include difficulty breathing and swallowing, Type II show muscle weakness between ages 6 and 12 months, Type III is juvenile type unable to stand and walk.

Type IV causes muscle weakness, tremor and twitching.

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