During receptor mediated endocytosis, in order for a vesicle to bud from the membrane, the vesicle must have outer coat made of CLATHERIN protein, which is secured to the vesicle membrane with the help of the protein ADAPTIN.
What is receptor mediated endocytosis?
- Receptor-mediated endocytosis is a type of endocytosis in which a specific target molecule is captured by receptor proteins on the cell surface.
- The receptors, which are transmembrane proteins, aggregate in covered pits on the plasma membrane.
- The name stems from a covering of proteins on the cytoplasmic side of the pit known as coat proteins. Clathrin is the best-studied coat protein.
- Adaptins are a category of membrane proteins that mediate the interaction of transmembrane proteins with the clathrin protiens.
- Endocytosis is induced when receptors bind to their specific target molecules, and the receptors and their attached molecules are transported into the cell in vesicles.
- The coat proteins aid in this process by giving the vesicle its rounded form and assisting in its separation from the membrane.
Hence, Clathrin and Adaptin are the two coat proteins involved in receptor mediated endocytosis. the same is shown in the diagram provided below.
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