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Parkinson's disease is a brain disorder that may be caused by mutations in several genes that code for the production of
alpha-synuclein. Individuals who have Parkinson's disease exhibit symptoms such as uncontrollable tremors, difficulty
walking, and loss of coordination. How might geneticists determine where the mutations that cause Parkinson's disease
are located?
O PCR analysis
O gene mapping
O DNA fingerprinting
OSTR analysis
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Gene mapping refers to the techniques used in molecular biology to determine the position of genes on the same chromosome. Gene mapping can be used to develop linkage analysis.
In this case, the geneticists can use GENE MAPPING techniques in order to determine the position of specific mutations that cause Parkinson's disease.
Two or more genes are linked when they are close on the same chromosome, thereby being inherited as a unit (i.e., as a linkage block).
Linkage analyses enable us to determine the position of linked genes on the same chromosome.
Gene mapping techniques include the use of molecular markers whose segregation evidence the position of target genes to be mapped.
