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The most historically significant triangular trade was the transatlantic slave trade which operated between Europe, Africa and the Americas from the 16th to 19th centuries. Slave ships would leave European ports (such as Bristol and Nantes) and sail to African ports loaded with goods manufactured in Europe. There, the slave traders would purchase enslaved Africans by exchanging the goods, then sail to the Americas via the Middle Passage to sell their enslaved cargo in European colonies. Afterwards, the slave ship would sail back to Europe to begin the cycle again. The enslaved Africans were primarily purchased for the purpose of working on plantations to work producing valuable cash crops (such as sugar, cotton and tobacco) which were in high demand in Europe. Slave traders from European colonies would occasionally travel to Africa themselves, eliminating the European portion of the voyage.

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