Respuesta :
Excitation-contraction coupling is an event that brings about the conversion of electrical signals inducing a change in actin–myosin interactions bringing about mechanical response.
The following events explains muscle contraction in the order ---
e. A nerve impulse causes ACh to be released at a neuromuscular junction.
b. The T tubules carry the action potential to the interior of the muscle fiber.
d. Calcium ions are released into the sarcoplasm.
a. Calcium ions bind to troponin molecules on the actin myofilaments
c. The troponin-tropomysin complex moves, exposing active sites on the actin myofilaments.
e. The heads of myosin myofilaments bind to sites on the actin myofilaments, forming cross-bridges.
- In excitation-contraction that takes place, electrical signals induces the Acetocholine neurotransmitter to be released causing the release of calcium ions and this in turn bind to troponin.
- Binding of troponin changes the shape of the myofilament allowing tropomyosin to disjoin from the myosin binding sites exposing it.
- Then the heads of this myosin filaments are able to bind and induce a mechanical response.
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