Given what we know, we can confirm that an extra copy of chromosome 1, 2, 3, 4, or 5 results in more severe abnormalities than an extra copy of chromosome 21 due to the contents of each chromosome.
What makes the first 5 chromosomes so dangerous?
This has to do with the content of the chromosomes.
More specifically, the amount of content.
The first 5 chromosomes contain about 7% of the entire human genome each on average.
This means that any duplication of these chromosomes will affect a very wide variety of genes essential to human development.
Therefore, given that the first 5 chromosomes contain an added total of about 35% of the entire humane genome, we can confirm that extra copies of these chromosomes would interfere with just about every aspect of human development, thus making for very severe abnormalities.
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