The connections between the Louisiana Purchase and Indian Removal to lands west of the Mississippi River the government exchange Native-held land in the cotton kingdom east of the Mississippi for the land in west.
After the Indian Removal Act was signed in 1830, , then federal government was able to get the power to exchange Native-held land that is found in Mississippi for land to the west.
Therefore, Indian Removal Act can be regarded as the exploration of the Louisiana Purchase.
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