Glutamic amino acid is the non-essential amino acid and an excitatory neurotransmitter. When Glu is found in the core then the pKa of the side chain group increases.
pKa is the acid strength or the estimate that shows whether the solution is weak or strong acid. pKa less than zero is a strong acid and portrays the bonding of the proton by the acids.
In the Glu amino acid, the value of the pKa of the side chain functional groups increases as the amino acid is found in the interior of the water-soluble folded protein structure.
Therefore, the pKa of the side-chain increases.
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