The Spanish immunity to smallpox was the advantage that contributed to the Aztecs' defeat.
Which Spanish advantage contributed to the Aztecs defeat?
As the Spanish army besieged Aztec army for 93 days, the combination of their superior weaponry and a devastating smallpox outbreak enabled the Spanish to conquer the city.
Hence, the Spanish immunity to smallpox was the advantage that contributed to the Aztecs' defeat.
Therefore, the Option D is correct.
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