TNF paly an very important role in the growth of the primary and the secondary lymphoid organs.
The growth of lymphoid tissue in the gut is fueled by TNFa. Because TNF/Rorc(gt)/ mice, who express higher amounts of TNF but lack RORgt+ LTi cells, also generate lymphoid tissue in sites of inflammation, the development of this ectopic lymphoid tissue was not contingent on the presence of conventional RORgt+ LTi cells. Surprisingly, these animals produced a number of lymph nodes that resembled those of wild type animals in both structure and function. When stromal cells were activated during the late stages of embryogenesis and when an organ genic pathway that permitted the formation of lymph nodes was activated, TNF generation by F4/80+ myeloid cells located inside the anlagen was crucial.
To learn more about peripheral or secondary lymphoid organs with the help of the given link:
https://brainly.com/question/13553292
#SPJ4
