The one that is most directly contributed to the establishment of the National Research Act and the creation of the Belmont Report is The Tuskegee Study. Hence, the correct answer is The Tuskegee Study. Read below about The Tuskegee Study.
The Tuskegee Study of Untreated Syphilis in the Negro Male was a study conducted between 1932 and 1972 by the United States Public Health Service and the Centers for Disease Control and Prevention on a group of nearly 400 African Americans with syphilis.
Therefore, the correct answer is as given above
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The complete question goes thus:
Which of the following most directly contributed to the establishment of the National Research Act and the creation of the Belmont Report
A. Crash test research
B. Stem Cell research
C. The Tuskegee Study
D. The Human Genome Project