The bone marrow begins producing cells in the fourth month of fetal life.
Hematopoiesis establishes in the marrow and grows there until, at term. This process starts in the late first trimester when the bones are large enough to contain marrow cavities. Hematopoiesis can move outside of the bone marrow to various organs under conditions of prenatal and neonatal stress.
Between the bone spicules are the hematopoietic components. Both sinusoids and a robust circulatory network are present in the marrow. Pluripotent stem cells are the progenitor cells that give rise to all hematopoietic components and lymphoid cells.
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