Bladder cancer (BCa) is an endocrine-related tumor and the activation of androgen signaling pathways may promote bladder tumorigenesis.
We compiled the research on the effects of altering androgen signaling pathways on Bladder cancer therapy outcomes, both preclinical and clinical. A thorough analysis was done in December 2020. The following criteria were met by the papers we included: examining the effects of androgen signaling regulation on the results of Bladder cancer treatments through innovative preclinical and clinical studies. Eight clinical trials and six preclinical studies were found. Preclinical research shows that the activity of radiation, doxorubicin, cisplatin, gemcitabine, and the Bacillus Calmette Guerin may be affected by the modification of androgen receptor-related pathways.
Patients receiving treatment with 5-ARIs or androgen deprivation therapy (ADT) have a considerably lower relative risk of developing Bladder cancer again after transurethral resection of the bladder tumor (TURBT) (Relative risk: 0.50, 95 percent confidence interval: 0.30-0.82; p = 0.006). In patients using 5-ARIs, subgroup analysis showed a relative risk of BCa recurrence of 0.46 (95% CI: 0.22-0.95; p = 0.040). The ratio of T1 Bladder cancer patients in treated/control groups and the relative risk of BCa recurrence were found to be significantly negatively correlated. A promising technique to lower the recurrence rate of Bladder cancer, particularly in patients with early-stage disease, may involve 5-ARI therapy. To corroborate these early findings, additional research is required.
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