Nuclear import receptors (karyopherin) proteins bind to nuclear localization signals on newly synthesized proteins.
- DNA is contained by the nuclear envelope, which also establishes the nuclear compartment.
- Nuclear pore complexes can pass across the two concentric membranes that make up this envelope.
- Despite being one continuous membrane, the inner and outer nuclear membranes still have different protein compositions.
- A subfamily of transport receptors known as karyopherins collectively mediates nuclear transport of proteins and RNA through the nuclear pore complex.
- Karyopherins recognize certain nuclear localization or nuclear export signals to attach to their payloads.
- Transient interactions between the karyopherins and the nuclear pore complex enhance transport via the complex.
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