The coenzymes according to their involvement in the pyruvate dehydrogenase complex.
d. lipoate (lipoamide).
b. coa-sh.
e. [fad].
a. nad.
c. tpp.
- The oxidative decarboxylation of pyruvate, which results in the synthesis of acetyl-CoA, CO2, and NADH (H+) (1,-3), is catalyzed by the pyruvate dehydrogenase complex (PDC)3.
- By connecting the glycolytic pathway to the oxidative pathway of the tricarboxylic acid cycle, the PDC plays a crucial role in the oxidation of glucose.
- Mammals' PDC functions as a gatekeeper in the pyruvate metabolism to preserve glucose homeostasis in both the fed and fasted phases. Under various metabolic situations, tissues have carefully controlled PDC flux.
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