In the α helices of transmembrane proteins, the hydrophobic side chains face the outside of the membrane-spanning helix.
Transmembrane proteins are a type of integral membrane protein that spreads throughout the cell membrane. Many transmembrane proteins act as gates that allow the transport of certain substances across the membrane.
Transmembrane proteins basically act as gates or docking sites that allow or prevent substances from crossing the cell membrane.
Transmembrane proteins penetrate the entire plasma membrane. Transmembrane proteins are found in all types of biological membranes. Monotopic proteins are permanently attached to the membrane from only one side
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