In regards to neurotransmitters that drugs affect, cocaine is to Dopamine as nicotine is to acetylcholine.The stimulation of central nAChRs by nicotine which results release of a variety of neurotransmitters in the brain is most importantly dopamine.
Nicotine is release of dopamine in mesolimbic area and causes corpus stratum and frontal cortex.They stimulate the release of neurotransmitters , mimic and the effect of neurotransmitters on postsynaptic receptor which block these effect interfere with reputable of neurotransmitter once it release.
Nicotine act as simulator and depressant both to central nervous system. It causes the hormone epinephrine which further stimulates the nervous system and responsible for part of kick from nicotine the drug which induced feelings of pleasure and addiction.
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