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Oversensitivity to fluctuations in the noradrenergic neurotransmitter system is likely to be associated with affective instability in Histrionic personality disorders.

Histrionic personality disorder (HPD) is a mental health condition characterized by volatile emotions, a distorted self-image, and a strong desire to be noticed. People with HPD frequently engage in dramatic or inappropriate behavior in order to gain attention. Histrionic personality disorder is one of several "Cluster B" personality disorders that involve dramatic and erratic behavior.

Self-esteem in people with histrionic personality disorder is based on the approval of others rather than a genuine sense of self-worth. They have an overwhelming desire to be noticed and will frequently engage in dramatic or inappropriate behavior to gain attention. People with histrionic personality disorder frequently are unaware that their behavior and way of thinking are problematic.

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