In a severe protein-deficient diet, the portion of the bone matrix will be reduced are the organic component and Osteoid.
- The bone matrix (also known as the osteoid) is made up of approximately 33% organic matter (mainly Type I collagen) and 67% inorganic materials (calcium phosphate, mostly hydroxyapatite crystals). At the growing bone surface, osteoblasts appear as a simple, epithelial-like layer.
- The organic component of bone is mostly composed of type I collagen (90%), with the remaining 10% composed of noncollagenous proteins. Type Icollagen is a triple-helical molecule made up of three polypeptide chains, each of which contains around 1000 amino acids.
- Osteoblasts initiate the formation of bone tissue by secreting the osteoid as a series of specialised proteins. When the osteoid mineralizes, it and the neighbouring bone cells form new bone tissue.
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