The basis for the difference in how the leading and lagging strands of DNA molecules are synthesized is that DNA polymerase can join new nucleotides only to the 3' end of a pre-existing strand, and the strands are antiparallel. .
The basis of the difference between the leading and lagging strand is that DNA polymerase can join new nucleotides only to the 3' end to the growing strand.
The difference between them is that the leading strand is formed towards replication fork, while the lagging strand is formed away.
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