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Individuals with the disorder xeroderma pigmentosum are hypersensitive to sunlight, and mutations to the DNA in their skin cells are left uncorrected. Why are the mutations not corrected in individuals with this disorder? (A) The disorder makes cells unable to replicate DNA. (B) The disorder causes mitosis to stop during metaphase. (C) The disorder makes cells unable to form chromosomes. (D) The disorder causes cells to be unable to repair thymine dimers.

Respuesta :

People who have Xeroderma pigmentosum are overly sensitive to sunlight and have unrepaired DNA abnormalities in their skin cells. It is because the cells are unable to repair thymine dimers as a result of the disease. Mutations that impair the nucleotide excision repair pathway are the root cause of this illness. These dimers and other types of UV damage cannot be repaired if this pathway is unable to function.

The principal DNA lesion brought on by sunlight in human skin is the cyclobutane thymine dimer, which is a major contributor to skin cancer. Nucleotide excision repair is the sole recognized cellular repair process in humans for removing the dimer from DNA. Mutations can result in this disease that predisposes affected persons to the development of skin cancer, due to the disruption of the nucleotide excision repair (NER) pathway.

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