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The spontaneous loss of amino groups from adenine in DNA results in hypoxanthine, an uncommon base, opposite thymine. What combination of proteins could repair such damage? (A) nuclease, DNA polymerase, DNA ligase (B) telomerase, primase, DNA polymerase (C) telomerase, helicase, single-strand binding protein (D) DNA ligase, replication fork proteins, adenylyl cyclase

Respuesta :

The combination of proteins that can repair the spontaneous loss of amino groups from adenine in DNA that results in hypoxanthine, an uncommon base, opposite thymine is nuclease, DNA polymerase, DNA ligase.

Deamination is the process of  removal of an amine group that causes a structural change in the base. Adenine is deaminated to produce hypoxanthine, or 6-hydroxypurine. After DNA replication, hypoxanthine in the DNA can pair with cytosine and cause A:T to G:C transition mutations. Mutagens cause this deamination to happen. Adenine and cytosine are transformed into hypoxanthine and uracil, respectively, by nitrous acid by switching their amino groups for keto groups.

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