The metabolic breakdown of specialized brown fat deposits in certain animals is substantially increased during non-shivering thermogenesis.
Non-shivering thermogenesis is defined as an increase in metabolic thermogenesis (above basal metabolic rate) not associated with muscle activity.
It occurs primarily through brown fat metabolism, and to a lesser extent in skeletal muscle, liver, brain, and white fat.
Brown fat breakdown occur in human fetuses between 20 and 30 weeks of gestation. It accounts for only 2-6% of the total body weight of the infant and is found in six major locations:
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