The main distinction between an estrous cycle and a menstrual cycle is that during an estrous cycle, the endometrium that the uterus secretes is reabsorbed without significantly draining the body's fluid stores, but during a menstrual cycle, the endometrium is expelled.
Since the endometrium the uterus sheds during the menstrual cycle is expelled out while in the estrous phase, it is reabsorbed, the foregoing points lead us to the conclusion that this is the main distinction between the two.
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